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Cell adhesion molecules (CAMs) are increasingly recognized to play a key role in the regulation of cell migration and metastasis. In the present study we evaluated the involvement of the three classical adhesion receptors involved in tumor cell metastasis (E-selectin, L-selectin, and ICAM-1) and the HLA-G gene in their functional regulation. An in vitro murine fibrosarcoma model of in vivo tumor cell metastatic potential was used. The following human adhesion molecules were studied: E-selectin, L-selectin, ICAM-1, CD44, CD18, HLA-G, CD14, CD11a, CD11b, CD11c, CD36, CD54, and CD102. In addition, the expression of these molecules was studied in the mouse EMT6-L cells. The immune response mediated by the HLA-G system was evaluated in terms of the expression of the costimulatory molecules CD40 and CD86. Anti-HLA-G monoclonal antibodies (mAbs) were used to explore the effect of the HLA-G system on tumor cell metastasis. In addition, it was evaluated whether coculture of HLA-G(+) EMT6-L cells and autologous lymphocytes influenced the potential of tumor cells to metastasize. Three different anti-HLA-G mAbs (MEM
The US Department of Energy (DOE) has joined the cities of San Francisco, San Diego, Palo Alto, Davis, and others to pledge environmental funding for green buildings that contribute to the city’s climate goals. The announcement was made this week as part of President Obama’s Green Building Challenge, which seeks to increase the adoption of green buildings in the US and around the world.
“It’s crucial that we have leaders in our local, state, and federal government who prioritize our health and safety by prioritizing buildings that are responsible for avoiding global warming,” Energy Secretary Stephen Chu said during a press conference today. “And that’s exactly what this Green Building Challenge does.”
But there’s a good bit more in the press release than that. The announcement is timed with the release of a new DOE report that names the “best practice” green buildings and shows how to locate them.
San Francisco, for example, is investing $2 million in a new technology that will make buildings self-clean in the future. The technology means that when the sun goes down, the heating systems in large structures will stop turning on, and the air in the buildings will be a consistent temperature. Even if the outside temperature goes up, the air will be colder, which is as close to a perfect ventilation system as we’re likely to get.
San Diego also wants to make sure it has clean air, clean water, and high-quality buildings. The city has a number of projects under way to strengthen its solid waste water treatment facilities.
It’s pretty obvious why the cities are going for these types of projects. The average building is responsible for 25 percent of US electricity use, and the bill gets passed down to us on our monthly electric bills. A smaller percentage of power and a lower bill gets us over the hump. Green buildings make a difference.
We’ve seen plenty of this push in the past. Although it’s not the first green building certification that DOE has introduced, it is the first to commit to funding green projects. DOE has always had a standard to meet, but the newly-created Green Building Challenge is the first to fund these projects.
The press release states that the new challenge will offer a number of incentives, including grants to small businesses and state/local governments. The Challenge will start with four pilot cities, and others may be added later.
“As we pursue a comprehensive energy policy that positions the United States as a leader in clean energy, the adoption of green buildings